Gene-targeted CEP164-deficient cells show a ciliation defect with intact DNA repair capacity
نویسندگان
چکیده
Owen M. Daly, David Gaboriau, Kadin Karakaya, Sinéad King, Tiago J. Dantas, Pierce Lalor, Peter Dockery, Alwin Krämer and Ciaran G. Morrison* Centre for Chromosome Biology, School of Natural Sciences and Anatomy, School of Medicine, National University of Ireland Galway, Galway, Ireland; Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
منابع مشابه
CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity.
Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium formation. Recent data have implicated CEP164 as a ciliopathy gene and suggest that CEP164 plays some roles in the DNA damage response (DDR). We used reverse genetics to test t...
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تاریخ انتشار 2016